Cardiopulmonary Assessment
Symptoms such as breathlessness, fatigue and an inability to exercise to the correct level are optimally investigated through CPET (CardioPulmonary Exercise Testing). CPET helps us to distinguish between the major cause of limitation (lung, heart, cardiovascular, muscular) and within each area, the specific cause of limitation. One test - diagnosis. Dyspnoea of unknown cause is optimally investigated with this technique. CPET is also essential in the following areas: -
Unique Diagnosis
The testing technique of CPET saves time and lowers patient risk levels as it is minimally invasive, straightforward to perform and patients find the test non-intimidating and tolerable. CPET can be uniquely utilised in the establishment of diagnosis in the following circumstances:
- Myocardial dyskinesis with myocardial ischemia during exercise
- Chronic heart failure due to diastolic dysfunction
- Pulmonary Vascular Occlusive Disease without pulmonary hypertension (pulmonary vasculopathy)
- Patent foramen ovale with right-to-left shunt during exercise
- Pulmonary vascular disease limiting exercise in chronic obstructive pulmonary disease
- Impaired muscle bioenergetic function
- Psychogenic dyspnea and behavioural causes of exercise intolerance
Device Management
This unique service of the Cardiopulmonary Centre draws upon our years of experience in pacemaker/ICD device optimisation. Paced patients with shortness of breath often require assistance from their pacemaker to achieve the required heart rate for particular levels of exertion. Setup of these 'rate response' parameters has previously been calculated upon a trial-and-error basis, with experience and multiple visits required to achieve optimum pacing response to exercise. At The Cardiopulmonary Centre we are pioneering an integrative approach to device setup - with only one patient visit required both to optimise pacing parameters, and minimise pacemaker-mediated dyspnoea. The same techniques can also be applied to objectively assess optimum medication therapy in patients with a variety of medical disorders.
Pre-Operative
Patients at London Bridge Hospital awaiting major surgery will benefit from a risk-assessment evaluation preoperatively and in certain cases postoperatively. CPET has been demonstrated to indicate risk of morbidity, recovery and disability following major surgery. This is especially relevant for patients undergoing thoracotomy or cardiac surgery.
Heart Failure Assessment
The measurements taken in our cardiopulmonary exercise tests have been found to be the best predictor of survival time in chronic heart failure patients. As an adjunct to this, with CPET we can differentiate right & left heart failure and the contribution of different organ systems to exercise limitation by assessing the adequacy of the performance of various elements in the pulmonary to cellular gas exchange circuit. This is a complicated analysis, but with our extensive experience in this field we are able to provide clearly defined reporting of heart failure status. This can often provide considerable reassurance for heart failure patients.
References
Chua TP, Ponikowski P, Harrington D, Anker SD, Webb-Peploe K, Clark AL, Poole-Wilson PA, Coats AJ. Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol 1997;29:1585-1590.
Kleber FX, Vietzke G, Wernecke KD, Bauer U, Optiz C, Wensel R, Sperfeld A, Glaser S. Impairment of ventilatory efficiency in heart failure: prognostic impact. Circulation 2000:101:2803-2809.
Gitt AK, Wasserman K, Kilkowski C, Kleeman T, Kilkowski A, Bangert M, Schneider S, Schartz A, Senges J. Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death. Circulation 2002;106:3079-3084
Koike A, Itoh H, Doi M, Taniguichi K, Marumo F, Umehara I, Hiroe M. Effects of isosorbide dinitrate on exercise capacity in cardiac patients. Relationship between oxygen uptake responses and hemodynamic effects. Jpn Circ J 1990;54:1535-1545.
Weber KT. What can we learn from exercise testing beyond the detection of myocardial ischemia? Clin Cardiol 1997;20:684-696.
Older P, Smith R, Courtney P, Hone R. Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise testing. Chest 1993;104:701-704.
Smith TP, Kinasewitz GT, Tucker WY, Spillers WP, George RB. Exercise capacity as a predictor of post-thoracotomy morbidity. Am Rev Respir Dis 1984; 129:730-734.
Stevenson LW. Role of exercise testing in the evaluation of candidates for cardiac transplantation. In: Wasserman K, ed. Exercise gas exhange in heart disease. Armonk, NY: Futura Publishing, 1996:271-286.
Treese N, MacCarter D, Akbulut O, Coutinho M, Baez M, Liebrich A, Meyer J. Ventilation and heart rate response during exercise in normals relevance for rate variable pacing. Pacing Clin Electrophysiol 1993;16: 1693-1700.

